Ontology

ChEBI

Chemical Entities of Biological Interest

An ontology of small molecules, including neurotransmitters, neuromodulators and neuroactive drugs, with their chemical roles.

chemistryneurotransmittersdrugsOBO Foundry
A85

FAIR 47/48

Version 256

Evaluated 27 Oct 2026

How scores work

Source & access

Homepageebi.ac.uk Repositorygithub.com DownloadCanonical file / PURL Browse in OLSEMBL-EBI Ontology Lookup ServiceBrowse in BioPortalNCBO BioPortalBrowse in OBO FoundryOBO Foundry registry

Portals & registries

SourceIDVersionClassesPropertiesIndividualsLoaded
OLS (EMBL-EBI)chebi256238,15048027 Oct 2026
TIB Terminology Servicechebi—000—
OBO Dashboardchebi—224,691——8 May 2026

Ontology IRI http://purl.obolibrary.org/obo/chebi.owl
Version IRI http://purl.obolibrary.org/obo/chebi/256/chebi.owl

Languages en

Imports from (3)
IAO RO BFO

Reused by (115)
ADO AGRO APOLLO_SV CHMO CIDO CLO COB CTENO CTO DDPHENO DIDEO DOID DPO DRON ECTO ENVO FBcv FOBI FOODON FYPO GENEPIO GENO GSSO HPO IDO INO MAXO MCO MONDO MOP MP NBO NCRO OBA OBI OBIB OHD OMP ONS OPMI ORNASEQ PECO PHIPO PORO PR PROCO RBO RXNO SCDO STATO TO TXPO UBERON UPHENO VO WBPhenotype XPO ZP AddictO AFO AISM BAO BCGO BCO BMONT CAO CARO CDNO CHEMINF CHIRO CL CMPO COVOC DISDRIV ECAO ECO ECOCORE EFO ENM EUPATH EXMO FIDEO FLOPO FOVT GO HCAO ICEO ICO IDOCOVID19 IDOMAL MFMO MICRO MSIO NGBO OBCS OGSF OHMI OHPI OMIABIS OMIT ONE OVAE PATO PBPKO PCL PDRO PREFER PRIDE PSDO RO SLM SLSO VALUESETS VBO XCO

Logical consistency
consistent · 0 unsatisfiable
OWL 2 DL
no
ROBOT report
0 errors · 400,509 warnings · 964 info
OBO principles
FP01FP02FP03FP04FP05FP06FP07FP08FP09FP11FP12FP16FP20
Axioms
3,808,597 · 0.02% entities reused

Also registered as
aberowl: CHEBI biodivportal: CHEBI bioportal: CHEBI fairsharing: FAIRsharing.62qk8w obofoundry: chebi ols: chebi ontobee: CHEBI tib.ts: chebi wikidata.entity: Q902623

Automated evaluation

F Findable FAIR12/12
  • Persistent identifier (F1)purl.obolibrary.org+4
  • Indexed in services (F4)5: OLS, BioPortal, OBO Foundry, Bioregistry, FAIRsharing+5
  • Citable reference (F2)doi:10.1093/nar/gkv1031+3
A Accessible FAIR12/12
  • Homepage reachableHTTP 200+3
  • Artefact retrievable over HTTP(S) (A1)download HTTP 200+6
  • Metadata persists in a registry (A2)OBO Foundry, Bioregistry+3
I Interoperable FAIR12/12
  • Formal machine-readable format (I1)OWL, OBO+5
  • Semantic-web IRIs (I2)OWL, OBO+3
  • References other vocabularies (I3)imports 3: iao, ro, bfo+4
R Reusable FAIR11/12
  • Clear license (R1.1)CC BY 4.0+5
  • Release provenance (R1.2)256 (version IRI in the artefact)+4
  • Community standards (R1.3)OBO principles: 10/13 checks pass+2
Q Ontology consistency & quality17/20
  • Logical consistencyconsistent, 0 unsatisfiable classes (OBO Dashboard)+10
  • OWL 2 DL profileoutside OWL 2 DL0
  • Upper-ontology alignmentimports BFO+3
  • Standard relations (RO)imports RO+1
  • ROBOT report: no errors0 errors+2
  • ROBOT report: warning density400509 warnings / 224691 classes = 1.780
  • Pitfall scan: no critical pitfallsno pitfall scan yet; ROBOT report has 0 errors+1
M Maintenance10/16
  • Recency2026-10-06 → 0.7 months (≤ 3 months)+10
  • Release cadence (12 months)0 releases0
U Community adoption11/16
  • Documented adopting projects2 projects+2
  • Reused by other ontologies115: ado, agro, apollo_sv, chmo, cido, clo…+4
  • Community signalmax(stars 51 → 2, citations 1084 → 5)+5
P Penalties (inactivity & inconsistency)0
  • Time since last activity0.1 years → 4 × max(0, 0.1 − 1)0
  • Inactive statusnot archived, legacy or inactive0
  • Consistencyconsistent, no unsatisfiable classes0

FAIR subtotal 47/48 · earned 85/100 = 85/100 → grade A

Community adoption 2

  • rhea-db.org

    Rhea uses CHEBI to annotate reaction participants

    Source: OBO Foundry registry
  • zfin.org

    ZFIN uses CHEBI to annotate experiments

    Source: OBO Foundry registry

Know a project that uses ChEBI? Suggest it.

History & changes 2 runs

26 Oct 2026: 8527 Oct 2026: 85Score over time
Metrics across runs
27 Oct 2026
rubric v3.5		26 Oct 2026
rubric v3.4
Score8585
Findable1212
Accessible1212
Interoperable1212
Reusable1111
Quality1717
Maintenance1010
Adoption1111
Penalty00
Logically consistentyesyes
Unsatisfiable classes00
In OWL 2 DLnono
ROBOT errors00
ROBOT warnings400,509400,509
Imported vocabularies33
Reused by115115

Newest run first. Highlighted cells changed since the run before; hover to see the earlier value. A rubric change alone can move points.

No changes detected between runs.

RunScoreFAIRVersion evaluatedTermsSnapshot
27 Oct 2026, 21:58 UTC85 A47256238,150JSON
26 Oct 2026, 03:31 UTC85 A47256238,150JSON

Provenance

Every fact on this page was fetched automatically. Each row shows where it came from and when. If a source fails, the last good value is kept and marked “carried forward”.

FactSourceRetrieved
Homepage link check (HTTP 200)ebi.ac.uk27 Oct 2026, 21:58 UTC
Repository link check (HTTP 200)github.com27 Oct 2026, 21:58 UTC
Download link check (HTTP 200)purl.obolibrary.org27 Oct 2026, 21:58 UTC
Artefact header (version IRI)ftp.ebi.ac.uk27 Oct 2026, 21:58 UTC
Git refs (commit 7b28409)github.com27 Oct 2026, 21:58 UTC
GitHub repository statisticsapi.github.com27 Oct 2026, 21:58 UTC
OLS classes, imports, version & releaseebi.ac.uk27 Oct 2026, 21:58 UTC
OBO Foundry status, license & usagesobofoundry.org27 Oct 2026, 21:58 UTC
TIB Terminology Service metricsservice.tib.eu27 Oct 2026, 21:58 UTC
Bioregistry mappings, dependencies & reusebioregistry.io27 Oct 2026, 21:58 UTC
OBO Dashboard (checked 8 May 2026)dashboard.obofoundry.org27 Oct 2026, 21:58 UTC
Crossref citations (doi:10.1093/nar/gkv1031)api.crossref.org26 Oct 2026, 02:43 UTC carried forward

Run 2026-10-27T21-58-30Z · evaluator v2.0.0 · rubric v3.5 · entry.json · run snapshot

How to cite